Self immolative polymers
WebNov 14, 2024 · Schematic representation of a self-immolative compound. The nitro group (NO 2) is a functional group composed of one nitrogen and two oxygens. Since the nitrogen atom bears a positive charge, the nitro group has typical reactivity due to its very strong electron-withdrawing nature. WebSelf-immolative polymers (SIPs) are a unique type of mols. that respond to external stimuli by undergoing head-to-tail disassembly through a self-immolative fragmentation. We have demonstrated how these polymers can be applied as activity-linked labeling probes for … American Chemical Society
Self immolative polymers
Did you know?
WebSelf-immolative polymers, designed to release a chemical moiety, or a plurality of chemical moieties, upon a pre-determined cleavage event, or sequences of events, are disclosed. The polymers can be simple polymers, comb polymers or branched polymers. Further disclosed are methods of usage, compositions and articles-of-manufactures containing ... WebSelf-immolative polymers (SIPs) are unique macromolecules that are able to react to multiple types of environmental influences by giving amplified response outputs. When triggering moieties installed at SIP chain ends are activated by their corresponding stimuli, a spontaneous head-to-tail depolymerization ensues, often involving multitopic ...
WebJun 15, 2015 · Self-immolative linear polymers are a recently developed class of materials that typically undergo head-to-tail depolymerization in response to the cleavage of stimuli-responsive end-caps from their termini. These polymers have been inspired by self-immolative dendrimers and oligomers that undergo cascades of cyclization and/or … WebSep 16, 2015 · Abstract. Upon stimuli-triggered single cleavage of capping moieties at the focal point and chain terminal, self-immolative dendrimers (SIDs) and linear self …
Webin smart materials and devices. Inspired by the notion of self-destruction, polymers that depolymerize end-to-end upon triggering have often referred to as self-immolative polymers (SIPs). 8. Other naming conventions including continuous head-to-tail depolymerization. 9. and cascade depolymerization. 10. have also been used. Webwall is a self-immolative cross-linked polymer network (blue) with a loaded trigger (star). The capsule releases its contents upon activation from a triggering event. This event removes the head of the polymer (star), initiating a head-to-tail depolymerization and release of the core contents. Scheme 1. Synthesis of Self-Immolative Polymers
WebAug 21, 2024 · Self-immolative polymers (SIPs) have been under development for over a decade, and efforts for their application followed shortly after their inception. One main area of application of SIPs is biomedicine, where they are used to construct devices and biosensors, develop new biotechnology abilities, or directly interface with the living system.
WebSep 24, 2008 · Polymers that can be triggered to disassemble in a sequential fashion following a single triggering event were described recently. The amplification effect after … rational krakowWebApr 23, 2008 · Smart polymers are special kinds of polymeric molecules that respond to external stimuli. We have developed a novel smart polymer designed to sequentially … rational jazz team serverWebSelf-immolative polymers (SIMPs) are macromolecules that spontaneously undergo depolymerization into small molecules when triggered by specific external stimuli. We … rational rose javaWebNov 1, 2024 · Self-immolative linkers, or spacers, are covalent groups, which have the role of cleavaging two bonds between a protector group and a drug, in the case of drug delivery systems, after a stimuli.The cascade of reactions allows to control the release of the drug. rational jazzWebSelf-Immolative RAFT–Polymer Protein Conjugation By applying excess symmetrical nitrophenyl carbonate disulfides to the RAFT end groups, protein-reactive end groups can … rationalwiki gnosticWebThe self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro ... dr riz ayobWebJun 15, 2015 · Self-immolative linear polymers are a recently developed class of materials that typically undergo head-to-tail depolymerization in response to the cleavage of stimuli … rational photography kolkata