Rel homology region

Author: ewyv

August undefined, 2024

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and pr… WebTranscription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. ... 4.1 Class: RHR (Rel homology region) 4.1.1 Family: Rel/ankyrin; NF-kappaB; 4.1.2 Family: ankyrin only; 4.1.3 Family: NFAT (Nuclear Factor of Activated T-cells) (NFATC1, NFATC2, NFATC3) 4.2 Class: STAT

Catalytic domain of deubiquitinylase USP48 directs interaction with Rel …

WebMar 1, 1994 · Within the Rel homology region of NF-kappa B p50 (also known as KBF1), two amino acid residues were identified by photocrosslinking to adjacent bases in a beta-interferon regulatory element. WebJun 22, 1999 · The Rel homology region of NFAT5 showed 41–45% identity with NFAT1–4 and 15–17% identity with p50 NF-κB in pairwise comparisons (Fig. 2 a and b), indicating … jean macarthur

Structure of the NF-κB p50 homodimer bound to DNA Nature

WebFeb 24, 1995 · Within this region, there is a span of ∼300 amino acids that shows a low level of sequence identity with the Rel homology region (RHR) previously recognized in Rel … WebThe rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain. The rel family comprises … WebRel Homology Domain. 92,93 The RHD is also known as the DNA-binding domain (DBD) of NFAT proteins, which shows a structural similarity to the DBD of nuclear factor-κB (NF … jean mace gare

Structural Requirements for Assembly of the CSL ... - ScienceDirect

WebThe Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, [2] including both NF-κB and NFAT, among others. Some of these transcription factors appear to form multi-protein DNA -bound complexes. [3] … WebFeb 1, 1994 · Within the Rel homology region of NF-kappa B p50 (also known as KBF1), two amino acid residues were identified by photocrosslinking to adjacent bases in a beta … jean maceWebJul 30, 2015 · The mammalian NF-κB family consists of five members: p65/RelA, RelB, c-Rel, p50 and p52, which share structural homology in their N termini with the retroviral oncoprotein v-Rel. via this rel homology region (RHR) they form stable homo- … lab paragraf 176

"WebNov 21, 2006 · The Rel homology domain (RHD) is an evolutionarily conserved DNA-binding and dimerization domain that is present in two main families of proteins: ... a 348 amino … " - Rel homology region

Rel homology region

The RelA NF-κB subunit and the aryl hydrocarbon receptor …

WebJan 9, 2024 · Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA. This study provides first evidence that the USP domain of USP48 is important for the physical association with substrate proteins, and a suitable target for small … Webbinding (Rel homology) region of NFAT family proteins (top). A wide-range genomic view of NFATc1 and NFATc2 genes suggests that these genes were generated by chromosomal gene duplication (bottom). (B) Loss-of-function analyses of NFATc2 in osteoclast differentiation. Microradiographic analysis of femur derived from NFATc2 / mice at

Did you know?

WebFeb 1, 1995 · The 1165 (RclAI, c-M. RelB. u-Rel, Dorsal and Dif pro- tetns are composed of Rrl homology regions and non-homologous transcrip- honal actlvatlon domains (indicated with rliiierent colors). Reprinted with pPrmi~Gon from I I I. Rel homology region plO5 IltB-like doman I p.50 I P52 L RelB - Dorsal r- 0 Current Biology Ltd ISSN 1074-5521 77?78 … WebJun 6, 2003 · Using bioinformatics tools, we identified a Rel homology region (RHR) within CSL that was used as a guide to determine the minimal protein requirements for ternary complex formation. The RHR of CSL contains both the N- and C-terminal beta-sheet domains (RHR-n and RHR-c) of typical Rel transcription factors, as judged by circular dichroism …

WebThe JASPAR CORE database contains a curated, non-redundant set of profiles, derived from published collections of experimentally defined transcription factor binding sites for eukaryotes. The prime difference to similar resources (TRANSFAC, etc.) consist of the open data access, non-redundancy and quality. When should it be used? When seeking ... WebFeb 13, 2024 · The vertebrate p53 homologs generally share low sequence homology in regions other than their DNA-binding domains (Ou et al., 2007; Lu & Abrams, 2006). In line with ... in these short sequences is difficult to detect. However, the conservation of the REL motif in some interfaces, coupled with the structural ...

WebNuclear factor of activated T cells (NFAT) and recombination signal binding protein (RBP) belong to the family of Rel homology region (RHR) transcription factors which regulate … WebFeb 1, 1994 · Europe PMC is an archive of life sciences journal literature.

WebDec 30, 2024 · Passionate about developing regional and global tech innovation ecosystems and champion of the Global Innovation …

WebNov 16, 2000 · The Rel homology region (RHR) is known to be important both for dimerization of NF-κB/Rel subunits (Grimm and Baeuerle, 1993), as well as for interaction … jean macé gareWebJun 6, 2003 · Detection of the Rel Homology Regions of CSL—The major isoform of human CSL encodes a protein of 486 amino acids (Fig. 1A).Known biochemical activities of CSL include sequence-specific DNA binding (29), association with ICN polypeptides (5), and formation of higher order complexes with MAML polypeptides (11, 12).To investigate the … jean macedoWebRel Homology Region (RHR) Class I p50 Class II p65 c-Rel ReIB C kB DNA N N N N C C p50 RHR p50 D256 N200 F213 p65 GGG5´ Y269 R56 R58 H66 Y59 p65 RHR C p52 A CD F E B NTD DimD LG 433 NTD DimD L 447 NTD DimD TADL 551 N NTD DimD TAD 619 Amino-terminal domain Dimerization domain C Linker L LZ NTD DimD L TAD 557 G Figure2. The … lab parafilmWebFeb 1, 1996 · The defining characteristic of Rel proteins is a stretch of roughly 300 amino acids called the Rel homology region (RHR) or Rel homology domain (RHD), within which … lab parahita bandungWebThe sequence of this region of NFATp shows a low degree of similarity to the Rel homology region. One specific short sequence in NFATp (RAHYETEG), located near the NH2 … lab pantaiWebThe sequence of this region of NFATp shows a low degree of similarity to the Rel homology region. One specific short sequence in NFATp (RAHYETEG), located near the NH2 terminus of the DNA-binding domain, … jean mace lrWebMar 21, 2024 · The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. lab par aati hai dua