Phospholipase a2 receptor antibody pla2r

WebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). WebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the MN field . Until recently, we lacked experimental evidence that PLA2R was indeed the culprit antigen that triggered the disease, mainly because it is not expressed on mouse podocytes.

The Diagnosis Accuracy of PLA2R-AB in the Diagnosis of ... - PLOS

WebDec 15, 2024 · The discovery of the phospholipase A2 receptor (PLA2R) antibody in 2009 has induced a paradigm shift in both the diagnosis and monitoring of patients. Two serological tests are routinely used: the enzyme-linked immunosorbent assay (ELISA), which is quantitative, and the immunofluorescence assay (IFA), which is more sensitive. WebAbstract. Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy … list of australia states and capitals https://horsetailrun.com

JCM Free Full-Text Membranous Nephropathy: From Research …

WebPhospholipase A2 Receptor (PLA2R) Antibody, ELISA - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing … WebSep 18, 2024 · Serum anti-phospholipase A2 receptor (PLA2R) antibody detected at diagnosis as a predictor for clinical remission in patients with primary membranous nephropathy: a meta-analysis Yufeng Liang, Jianxin Wan, Yongping Chen & Yangbin Pan BMC Nephrology 20, Article number: 360 ( 2024 ) Cite this article 7470 Accesses 11 … WebMar 11, 2024 · Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg−) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of … list of australian venture capital firms

THSD7 - Overview: Thrombospondin Type-1 Domain-Containing 7A Antibodies …

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Phospholipase a2 receptor antibody pla2r

Association of serum mannose-binding lectin, anti-phospholipase A2 …

WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay … WebPhospholipase A2 receptor (PLA2R) is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that it is a major antigen …

Phospholipase a2 receptor antibody pla2r

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WebBackground: The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The effects of anti-PLA2R antibodies directly to the podocytes remain unclear. WebThe discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary target in membranous nephropathy (MN) greatly advanced basic and clinical research. …

WebAnti-PLA2R antibody [CL0474] (ab188028) Datasheet SDS Submit a review Submit a question References (2) Key features and details Mouse monoclonal [CL0474] to PLA2R Suitable for: IHC-P, WB, ICC Reacts with: Human Isotype: IgG1 You may also be interested in Primary Anti-Ext1 antibody (ab126305) Peptide PLA2R peptide (ab176432) WebRecent clinical studies have revealed that circulating autoantibodies to the podocyte M-type receptor for secretory phospholipase A2 (PLA2R) can be measured in 70% to 80% of …

WebBackground: The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. Here, we conducted a comprehensive meta-analysis to … WebMar 5, 2015 · Hoxha, E. et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 82, 797–804 (2012).

WebMay 29, 2024 · The aims of this study were to detect the expression of M phospholipase A2 receptor (PLA2R) in the kidney tissue of patients with idiopathic membranous nephropathy (IMN), secondary membranous nephropathy (SMN), and the nonmembranous nephropathy (non-MN), to evaluate the value of PLA2R in the kidney tissue and serum anti-PLA2R …

WebThe Phosphlipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Autoantibodies directed to … list of austrian banksWebJan 3, 2024 · Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. images of older women with long gray hairWebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy (IMN).Methods A total of 233 patients with IMN proven by kidney biopsy at Peking Union Medical College Hospital from January 2012 to March 2014 were enrolled in this study ... images of old fashioned caroling song booksWeb180 kDa secretory phospholipase A2 receptor antibody; C-type lectin domain family 13 member C antibody; CLEC13C antibody; M type receptor antibody; ... Ramachandran R et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians. images of old fashioned henry hamburg kiteWebThrombospondin Type-1 Domain-Containing 7A Antibodies, Serum Specimen Fees & Codes Setup & Updates Useful For Distinguishing primary from secondary membranous nephropathy cases with antibodies against THSD7A Method Name Indirect Immunofluorescence Assay (IFA) NY State Available Yes Reporting Name THSD7A Ab, S … list of austrian princessesWebSep 18, 2024 · Currently, serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) is emerging as a predictive biomarker for early prognosis of PMN. In 2009, Beck et al. [ 2 ] … list of austrian artistsWebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay … images of old fashioned keys