Phenotypically modulated

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August undefined, 2024

WebAug 1, 2024 · In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of... WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue.

SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in …

WebApr 4, 2024 · Preview PDF Abstract Objective: Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic … WebJan 13, 2013 · We identified large numbers of phenotypically modulated SMCs in lesions that showed no detectible expression of MYH11 ( Fig. 4c) or ACTA2 ( Fig. 4d) and were identifiable as being of SMC origin... how to change your nonprofit name with irs

Smad3 Regulates Smooth Muscle Cell Fate and Governs …

WebOct 7, 2024 · To form the FC, SMC undergo phenotypic modulation in response to atherogenic stimuli and migrate from the media into atherosclerotic lesions. 5–7 Recent lineage tracing studies in mice revealed that SMC can be beneficial or detrimental in atherosclerotic lesions, depending on the specific SMC phenotypic transitions. 7–13 For … WebApr 15, 2014 · Studies within this dissertation are focused on identifying phenotypically modulated SMCs within atherosclerotic lesions using a newly developed conditional SMC specific lineage tracing mouse model, and a novel method that allows for the visualization of histone modifications of single genomic loci with single-cell resolution in formaldehyde ... WebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched … how to change your nominated pharmacy

Smooth muscle 22 alpha protein inhibits VSMC foam cell ... - Nature

Local Medial Microenvironment Directs Phenotypic Modulation of …

WebJan 23, 2009 · An accumulation of these phenotypically modulated SMCs within the diseased vessel contributes to plaque formation and the consequent narrowing of the vascular lumen. Our laboratory has had a long-standing interest in unraveling the molecular mechanisms that contribute to the phenotypic modulation of SMCs to prevent or reduce … WebSingle cell RNA sequencing (scRNA-Seq) identified phenotypically modulated SMCs (mSMCs) characterized by upregulation of macrophage, fibroblast, and chrondrocyte markers that appear with atherosclerotic plaque formation in Apoe-/- mice aortas. This transition is dependent on Kruppel-like factor 4 (Klf4). how to change your notification sound how to change your npi taxonomy

"WebOct 22, 2024 · To determine whether the dysfunction of the LXRα-ABCA1 axis is common in phenotypically modulated VSMCs, we performed the proteomic analysis of the contractile and synthetic VSMCs and showed that... " - Phenotypically modulated

Phenotypically modulated

Modulation of Smooth Muscle Cell Phenotype

We tested the hypothesis that phenotypically modulated smooth … WebNov 8, 2024 · The root system architecture (RSA) of plants is highly dependent on the surrounding nutrient environment. The uptake of essential nutrients triggers various signaling cascades and fluctuations in plant hormones to elicit physical changes in RSA. These pathways may involve signaling components known as small signaling peptides …

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WebFeb 8, 2024 · Differentially expression analysis revealed that, compared to Rgs5 low SMCs, Rgs5 high SMCs expressed significantly higher levels of molecular signatures for phenotypically modulated SMCs as ... WebJun 26, 2008 · Animal Model KLF5 is a transcription factor for Smemb/nonmuscle myosin heavy chain B, which is a molecular marker of phenotypically modulated smooth muscle cells. Normally, KLF5 is abundantly expressed in developing blood vessels, but is downregulated in adult vessels.

WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female … WebThe phenotype of the intimal SMCs gradually returned to the differentiated-type from the deep intima after 2 months, but a small number of the intimal SMCs remained in the dedifferentiated phenotype even at 6 months after the operation.

WebJun 1, 2012 · Phenotypically modulated SMCs are characterized by a decreased expression of SMC-specific proteins and show a high degree of proliferation and the ability to … WebAug 31, 2012 · Previous studies have shown that SMC phenotype is actively regulated via transduction of growth factor-mediated and biomechanical signals to the nucleus …

WebKLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.

WebPhenotypic modulation refers to the unique ability of SMCs to alter their phenotype in response to extracellular stimuli and is hallmarked by the loss of SMC m … Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle Am J Physiol Heart Circ Physiol. michael williams actor biographyWebFeb 25, 2015 · In intimal lesions, we observed 2 phenotypically distinct subtypes of SMCs: hyperchromatic and oval cells staining positive for αSMA, vimentin, SM1 and HHF35 but … how to change your nintendo switch nameWebJan 1, 2024 · Phenotypic modulation Methods We summarize findings from extensive literature searches to highlight recent discoveries in the mechanisms underlying vascular smooth muscle cell (VSMC) phenotypic switching with particular relevance to intimal hyperplasia. PubMed was searched from January 2001 to December 2024. michael williams black \\u0026 veatchWebSep 15, 2024 · these SMC progenies have been previously lumped together as phenotypically modulated SMC, advances in single cell RNA profiling has demonstrated the presence of subsets of these cells with distinct transcriptomes and cell fates. For example, medial SMC have been shown to give michael william phillips obituaryWebApr 25, 2024 · During aneurysm formation, smooth muscle cells undergo a process known as phenotypic modulation. Although this process has been well-studied, the possible role … how to change your notary nameWebApr 25, 2024 · The effects of smooth muscle cell apoptosis and necrosis accompanied by extracellular matrix degradation is believed to be the major processes leading to the weakening of the aortic wall and could be one of the major causes of AAA rupture; however, the mechanisms that regulate AAA rupture remain unknown (Henderson et al. 1999; … michael williams bridgeforceWebThis increase in the number of phenotypically modulated perivascular cells was specific to pre-metastatic lung tissue, in that a similar expansion of perivascular cells was not seen in other... how to change your number on textnow