WebOct 22, 2014 · 4WQO. PubMed Abstract: The von Hippel-Lindau tumor suppressor protein (VHL) recruits a Cullin 2 (Cul2) E3 ubiquitin ligase to downregulate HIF-1α, an essential transcription factor for the hypoxia response. Mutations in VHL lead to VHL disease and renal cell carcinomas. Inhibition of this pathway to upregulate erythropoietin production is … WebApr 12, 2024 · The damaged DNA-binding protein 1 (DDB1) enhances the survival and maintenance of multipotent cells through promoting the Cullin 4 E3 ligase complex …
Biomolecules Free Full-Text The COP9 Signalosome: A …
WebCullin-RING ubiquitin ligases (CRLs) represent the largest superfamily of multi-subunit E3s conserved in all eukaryotes. Soon after the discovery of these important ubiquitin ligase machineries, structural studies have made tremendous contributions to our … WebApr 12, 2024 · Recently, DDB1 has been recognized as an adapter protein of Cullin 4A (Cul4A) E3 ligase complex [ 2 ]. CUL4-DDB1 E3 ligase (CRL4 DDB1) complex could target the downstream substrates for ubiquitination and subsequent degradation and then affect DNA repair, replication, and transcription [ 1 ]. chronical order pronunciation
Advances in the potential roles of Cullin-RING ligases in regulatin…
WebThe cullin-RING ligases (CRLs) are a highly polymorphic E3 collection composed of a cullin backbone onto which binds carriers of activated Ub and a diverse assortment of adaptors … WebApr 7, 2024 · E3s can be classified in three main types, depending on the presence of characteristic domains: the homologous to E6-AP C-terminus (HECT), really interesting new gene (RING), and RING-between-RING (RBR) domains [ 8 ]. The RING-type ubiquitin ligase family represents the most abundant human E3s with over 600 members [ 9 ]. WebAug 28, 2013 · Modular CULLIN-RING ubiquitin ligases (CRLs) are the most prevalent class of E3s, comprising hundreds of distinct CRL complexes with the potential to recruit as many and even more protein substrates. chronical or chronicle