Cisplatin ocular toxicity

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August undefined, 2024

WebNov 17, 2024 · Very common (10% or more: Neurotoxicity (e.g., somnolence, fatigue) Common (1% to 10%): Dizziness Uncommon (0.1% to 1%): Peripheral neuropathy Rare (less than 0.1%): Seizure (occasionally associated with allergic reactions ), optic neuritis, cortical blindness transient, neurotoxicity (e.g., somnolence, fatigue) WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor.

Ocular and orbital complications of intraarterial cisplatin. A …

WebCisplatin or PTX may affect optic nerve function, and the combination of CDDP with PTX may synergistically increase the neurotoxicity risk to the optic nerve. In our case, however, the primary cause of the patient’s ocular symptoms and blindness remain unknown. WebFeb 11, 2024 · Mannitol for the prevention of cisplatin-induced nephrotoxicity: A retrospective comparison of hydration plus mannitol versus hydration alone in inpatient and outpatient regimens at a large academic medical center Show details Hide details Robert P Williams Brandon W Ferlas Paul C Morales Andy J Kurtzweil Journal of Oncology … can i get newsmax on youtube tv

Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case ...

Webtoxicity, including acute renal failure. Ensure adequate hydration. Consider dose reductions or alternative treatments in patients with renal impairment. (2.1, 5.1) • Peripheral … WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was … WebIbrutinib ocular toxicity was second most common (5/31, 16.1%), usually causing red or dry eye, while one patient developed branch retinal artery occlusion. Retinal abnormalities documented on OCT imaging occurred with IFN-α (2b), ipilimumab, binimetinib, and docetaxel, while rod-cone ERG abnormality was seen with cisplatin. fit to paper pdf

Ophthalmic Complications Related to Chemotherapy in …

Effects of Achillea millefolium on cisplatin induced ocular …

Web5.7 Ocular Toxicity . 5.8 Secondary Malignancies . 5.9 Embryo -Fetal Toxicity . 5.1 0 Injection Site Reactions . 6 ADVERSE REACTIONS . ... x Neph ro toxicity: cisplatin for i njection can cause se vere renal toxicity, incl uding acute renal failure. Severe renal toxicities are dose- related and cumulative. WebSep 27, 2024 · Acute overdosage with cisplatin for injection may result in renal failure, hepatic failure, hearing loss, ocular toxicity, myelosuppression, nausea and vomiting, and neuritis. fit to paper widthWebCisplatin and topoisomerase inhibitor type II have been found to cause central retinal artery occlusions, and retinal vein occlusions have been seen with vandetanib (Caprelsa, Genzyme). 2,3,5-7 These changes should be … fit to page word print

"WebApr 11, 2024 · Toxicity of intracarotid etoposide phosphate and carboplatin was reported in a 52-year old-male patient with glioblastoma multiforme. Citation 7 After 7 h of drug administration, it was observed that non-pupillary block angle-closure glaucoma developed secondary to uveal effusion in the ipsilateral eye (relieved by cycloplegia). " - Cisplatin ocular toxicity

Cisplatin ocular toxicity

Known and novel ocular toxicities of biologics, targeted ... - PubMed

WebNational Center for Biotechnology Information WebThe main drugs with retinal toxicities are interferon alpha 2b, denileukin diftitiox, and the monoclonal antibodies, ipilimumab and trastuzumab (Table 2). Table 2: Biologics and Associated Retinal Toxicities Interferon alpha 2b This is a recombinant protein widely used in the treatment of inflammatory and infectious diseases, such as hepatitis C.

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WebFeb 11, 2024 · Mannitol for the prevention of cisplatin-induced nephrotoxicity: A retrospective comparison of hydration plus mannitol versus hydration alone in inpatient … WebApr 19, 2024 · Ototoxicity, which may be more pronounced in children, and is manifested by tinnitus, and/or loss of high frequency hearing and occasionally deafness, is significant. Anaphylactic-like reactions to PLATINOL have been reported. Facial edema, bronchoconstriction, tachycardia, and hypotension may occur within minutes of …

WebNational Center for Biotechnology Information WebCisplatin therapy may cause neurologic complications, and i.a. delivery has been reported to cause ocular toxicity. We report a patient who experienced intraorbital and intraocular toxicity following supraophthalmic i.a. injection of cisplatin. Publication types Case Reports Research Support, Non-U.S. Gov't MeSH terms Adult

WebDec 13, 2024 · Also, ocular sections were evaluated histopathologically. Bromelain demonstrated a dose-dependent protective effect in cisplatin-induced toxicity by … WebAim: Cisplatin is a widely used and highly effective anti-cancer agent and one of the limiting side effects of cisplatin is ocular toxicity. Achillea millefolium , also known as yarrow, is …

WebFeb 15, 2024 · One study revealed patients being treated with cytarabine developed corneal deposits, irritating and causing a decrease in vision in up to 85% of patients. 4. The posterior segment is not spared with cytotoxic chemotherapeutics and should be monitored as well. It has been well documented that interferon-alfa 2b has many ocular side effects.

WebMar 9, 2024 · These reports suggest a dose-dependent retinal toxicity which can become clinically relevant in high-dose platinum-based regimens, as shown in two studies observing ocular pathologies due to miscalculated cisplatin dosages (100 mg/m 2 daily for 4 days) (Katz et al. 2003; Wilding et al. 1985 ). fit to paper wordWebNov 12, 2024 · Incidence not known Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation,... bleeding gums blindness … can i get news nation on rokuWebJan 5, 2024 · • A clinical trial of mobocertinib reported ocular toxicity in (including dry eye, eye pruritus, eye discharge, blepharitis, trichiasis, conjunctival hemorrhage, blurred … can i get newsmax on hulu liveWebcarboplatin, cisplatin, oxaliplatin; all have platinum; act like alkylating agents. ... neurotoxicity, ocular toxicity, cerebellar toxicity. how do you manage ocular toxicity of cytarabine? steroid eye drops. What is the drug interaction with mercaptopurine? allopurinol- won't clear as well. can i get newsnation on rokuWebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … can i get newsmax without cableWebAug 24, 2024 · Only a scanty number of cases have been reported on the ocular toxicity of carboplatin. Ocular symptoms described include pain, blurred vision, scattered blind spots, metamorphopsia and difficulty in reading. 2 – 5 Visual symptoms typically present between 5 and 14 days following carboplatin administration. fit to parentWebDec 13, 2024 · Also, ocular sections were evaluated histopathologically. Bromelain demonstrated a dose-dependent protective effect in cisplatin-induced toxicity by regulating oxidative stress, inflammation, and tissue damage. Our results suggested that bromelain may be a potential adjuvant that can protect the eye from cisplatin-induced toxicity. … can i get new york bagels shipped